A moneyline is a straight bet on which side wins a game outright, with no point spread involved, priced using American odds that show favorites as a negative number and underdogs as a positive one.
Kansas City is priced at -275 to beat Denver. A $275 wager on the Chiefs profits $100 if they win by any margin, so the total payout on a win is $375, the $275 stake plus $100 profit.
Denver sits at +220 in the same game. A $100 bet on the Broncos profits $220 if they pull off the upset, for a total payout of $320.
A point spread is a bet on the margin of victory rather than who simply wins, with the favorite required to win by more than the listed number of points and the underdog allowed to lose by less than it, or win outright.
An over/under, or totals bet, is a wager on whether the combined score of both teams in a game will finish above or below a number set by the sportsbook, with no bearing on which team actually wins.
The favorite is the side a sportsbook expects to win, marked with a minus sign in American odds, which means a bettor risks more than they stand to profit if that side comes through.